(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

Base Information

Chemical Name:(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate
CAS No.:1579996-86-3
Molecular Formula:C₂HF₃O₂*C₁₈H₁₉N₃O₂
Molecular Weight:423.392
Hs Code.:

Synonyms:(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

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Chemical Property of (S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

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Technology Process of (S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

There total 4 articles about (S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1579996-86-3
(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethylmorpholine;; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0 - 20 °C

2.1: potassium acetate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 11 h / Inert atmosphere; Reflux

3.1: potassium acetate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 6 h / Inert atmosphere; Reflux

4.1: dichloromethane / 0.25 h / 60 °C / Inert atmosphere

With N-ethylmorpholine;; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm401705g

Reference yield:

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

: 1579996-86-3
(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 11 h / Inert atmosphere; Reflux

2: potassium acetate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 6 h / Inert atmosphere; Reflux

3: dichloromethane / 0.25 h / 60 °C / Inert atmosphere

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm401705g

Reference yield:

: 1579996-83-0
(S)-tert-butyl-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-yl carbamate

: 1579996-86-3
(S)-2-amino-3-(4-(2-methyl-1-oxoisoindolin-5-yl)phenyl)propanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; acetonitrile / 6 h / Inert atmosphere; Reflux

2: dichloromethane / 0.25 h / 60 °C / Inert atmosphere

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm401705g