(S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride

Base Information

• Chemical Name: (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride
• CAS No.: 1001180-07-9
• Molecular Formula: C₉H₁₀ClNO₂*ClH
• Molecular Weight: 236.098
• Mol file: 1001180-07-9.mol

Synonyms:(S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride

Chemical Property of (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride

There total 1 articles about (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.8%

(S)-3-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)propanoic acid (1001180-04-6) → (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride (1001180-07-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield: 93.0%

(S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride (1001180-07-9) + di-tert-butyl dicarbonate (24424-99-5) → (S)-3-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)propanoic acid (1001180-04-6)

Guidance literature:

With tetramethyl ammoniumhydroxide; In water; acetonitrile; at 20 ℃; for 8h;

DOI:10.1021/jm301024w

Reference yield:

(S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride (1001180-07-9) → tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)carbamate (1001270-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetramethyl ammoniumhydroxide / acetonitrile; water / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 1 h / 20 °C

With tetramethyl ammoniumhydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile;

upstream raw materials:

(S)-3-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)propanoic acid

Downstream raw materials:

(S)-3-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)propanoic acid

tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)carbamate

C₂₇H₃₆ClN₅O₃

Refernces

• 1、 Blake, James F.,Xu, Rui,Bencsik, Josef R.,Xiao, Dengming,Kallan, Nicholas C.,Schlachter, Stephen,Mitchell, Ian S.,Spencer, Keith L.,Banka, Anna L.,Wallace, Eli M.,Gloor, Susan L.,Martinson, Matthew,Woessner, Richard D.,Vigers, Guy P.A.,Brandhuber, Barbara J.,Liang, Jun,Safina, Brian S.,Li, Jun,Zhang, Birong,Chabot, Christine,Do, Steven,Lee, Leslie,Oeh, Jason,Sampath, Deepak,Lee, Brian B.,Lin, Kui,Liederer, Bianca M.,Skelton, Nicholas J.. "Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors". . p. 8110 - 8127. Retrieved 2012/11/13.
• 2、 -. "CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS". Page/Page column 101. . Retrieved 2008/06/13.