(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Base Information

Chemical Name:(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one
CAS No.:603961-55-3
Molecular Formula:C₂₆H₃₇NO₅Se
Molecular Weight:522.543
Hs Code.:

Synonyms:(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Suppliers and Price of (7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Chemical Property:

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Technology Process of (7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

There total 12 articles about (7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 603961-54-2
(7R,8S,13S)-8,13-epoxy-7α,15-dihydroxylabdan-11-one

: 603961-55-3
(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Guidance literature:: With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 3.75h;
DOI:10.1016/S0040-4020(03)00788-9

Reference yield:

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 5-hydroxy-3-(2-hydroxy-ethyl)-3,4a,7,7,10a-pentamethyl-dodecahydro-benzo[f]chromen-1-one

: (3R,4aR,5S,6aR,10aR,10bS)-5-Hydroxy-3,4a,7,7,10a-pentamethyl-3-[2-(2-nitro-phenylselanyl)-ethyl]-dodecahydro-benzo[f]chromen-1-one

: 603961-55-3
(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Guidance literature:: With tributylphosphine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4020(03)00788-9

Reference yield:

: 303765-54-0
(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

: 603961-55-3
(7R,8S,13R)-8,13-epoxy-7-hydroxy-15-(o-nitrophenylselanyl)labdan-11-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 84 percent / sodium hydride / tetrahydrofuran / 20 °C

2.1: 4,4'-di-tert-butylbiphenyl; lithium / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 °C

3.1: o-iodoxybenzoic acid / dimethylsulfoxide / 20 °C

4.1: m-chloroperbenzoic acid / CHCl₃ / 20 °C

5.1: triflic acid / toluene / 0 °C

6.1: ceric ammonium nitrate / acetonitrile; H₂O

7.1: tri-n-butylphosphine / tetrahydrofuran / 20 °C

With ammonium cerium(IV) nitrate; tributylphosphine; trifluorormethanesulfonic acid; 4,4'-di-tert-butylbiphenyl; lithium; sodium hydride; 3-chloro-benzenecarboperoxoic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; chloroform; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(03)00788-9