(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

Base Information

Chemical Name:(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester
CAS No.:303765-54-0
Molecular Formula:C₁₉H₂₄O₆S
Molecular Weight:380.462
Hs Code.:

Synonyms:(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

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Chemical Property of (2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

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Technology Process of (2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

There total 5 articles about (2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 98-59-9
p-toluenesulfonyl chloride

: 209118-78-5
(2S)-4-(4-methoxyphenoxy)-2-methylbutane-1,2-diol

: 303765-54-0
(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

Guidance literature:: With pyridine; In chloroform; for 3h; Heating;
DOI:10.1016/S0040-4020(03)00788-9

Reference yield:

: 169310-73-0
1-methoxy-4-((3-methylbut-3-en-1-yl)oxy)benzene

: 303765-54-0
(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂OsO₂(OH)4; K₂CO₃; DHQ₂PHAL / K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 24 h / 0 °C

2: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h / 20 °C

With dmap; potassium dioxotetrahydroxoosmate(VI); potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; potassium hexacyanoferrate(III); In dichloromethane; water; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2007.04.031

Reference yield:

: 150-76-5
4-methoxy-phenol

: 303765-54-0
(2S)-toluene-4-sulfonic acid 2-hydroxy-4-(4-methoxyphenoxy)-2-methylbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / DIAD; PPh₃ / tetrahydrofuran

2: 95 percent / AD-Mix-α / H2O; 2-methyl-propan-2-ol

3: Et₃N; DMAP / CH₂Cl₂

With dmap; AD-mix-α; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1: Mitsunobu reaction / 2: Sharpless dihydroxylation;
DOI:10.1021/ja0652619