methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

Base Information

Chemical Name:methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate
CAS No.:120190-55-8
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

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Technology Process of methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

There total 4 articles about methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 120190-53-6
(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

: 120190-55-8
methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(01)86037-3

Reference yield:

: 120190-50-3
(2R,5S,1'R,2'R,3'R)-2,5-dihydro-2-(1'-hydroxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-5-isopropyl-3,6-dimethoxy-pyrazine

: 120190-55-8
methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 4-(dimethylamino)-pyridine / pyridine / Ambient temperature

2: 65 percent / 0.2N HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; dmap; In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4020(01)86037-3

Reference yield:

: 107384-38-3,134929-84-3
(E)-(S)-1-((2R,5S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-3-phenyl-prop-2-en-1-ol

: 120190-55-8
methyl (2R,3S,4R,5R)-2-acetamino-3-hydroxy-4,5-methylene-5-phenyl-pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / diethyl zinc / hexane / 3 h / 20 °C

2: 82 percent / 4-(dimethylamino)-pyridine / pyridine / Ambient temperature

3: 65 percent / 0.2N HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; dmap; diethylzinc; In tetrahydrofuran; pyridine; hexane;
DOI:10.1016/S0040-4020(01)86037-3