(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

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Chemical Name:(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine
CAS No.:120190-53-6
Molecular Formula:C₂₁H₂₈N₂O₄
Molecular Weight:372.464
Hs Code.:

Synonyms:(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

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Chemical Property of (2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

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Technology Process of (2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

There total 4 articles about (2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-24-7
acetic anhydride

: 120190-50-3
(2R,5S,1'R,2'R,3'R)-2,5-dihydro-2-(1'-hydroxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-5-isopropyl-3,6-dimethoxy-pyrazine

: 120190-53-6
(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

Guidance literature:: With dmap; In pyridine; Ambient temperature;
DOI:10.1016/S0040-4020(01)86037-3

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 120190-53-6
(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

Guidance literature:: Multi-step reaction with 3 steps

2: 61 percent / diethyl zinc / hexane / 3 h / 20 °C

3: 82 percent / 4-(dimethylamino)-pyridine / pyridine / Ambient temperature

With dmap; diethylzinc; In pyridine; hexane;
DOI:10.1016/S0040-4020(01)86037-3

Reference yield:

: 107384-38-3,134929-84-3
(E)-(S)-1-((2R,5S)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-3-phenyl-prop-2-en-1-ol

: 120190-53-6
(2R,5S,1'R,2'R,3'R)-2-(1'-acetoxy-2',3'-methylene-3'-phenyl-prop-1'-yl)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / diethyl zinc / hexane / 3 h / 20 °C

2: 82 percent / 4-(dimethylamino)-pyridine / pyridine / Ambient temperature

With dmap; diethylzinc; In pyridine; hexane;
DOI:10.1016/S0040-4020(01)86037-3