2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

Base Information

Chemical Name:2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid
CAS No.:1350961-29-3
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

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Chemical Property of 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

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Technology Process of 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

There total 8 articles about 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1350846-87-5
ethyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoate

: 1350961-29-3
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

Guidance literature:: ethyl 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoate; With sodium hydroxide; In ethanol; at 20 ℃; for 5h;

With hydrogenchloride; In water;
DOI:10.1021/jm201306q

Reference yield:

: 198756-78-4
C₂₀H₂₃NO₅

: 1350961-29-3
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C / 3800.26 Torr

2.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 15 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0.5 h / Reflux; Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

5.1: sodium hydroxide / ethanol / 5 h / 20 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; triethylamine; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm201306q

Reference yield:

: 1350846-83-1
ethyl 2-[4-(2-heptanoylaminoethyl)phenoxy]ethanoate

: 1350961-29-3
2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 0.5 h / Reflux; Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 18 h / 0 °C / Reflux

3.1: sodium hydroxide / ethanol / 5 h / 20 °C

With borane-THF; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm201306q