2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

Base Information

Chemical Name:2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine
CAS No.:1374342-54-7
Molecular Formula:C₂₅H₂₄F₄N₂
Molecular Weight:428.473
Hs Code.:

Synonyms:2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

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Chemical Property of 2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

Chemical Property:

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Technology Process of 2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

There total 4 articles about 2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20885-12-5
2-chloro-6-fluoropyridine

: 1374342-52-5
4-[4'-methyl-2'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl-4-yl]-1-(2,2,2-trifluoroethyl)piperidine

: 1374342-54-7
2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 90 ℃; for 4h; Inert atmosphere; Sealed tube;

Reference yield:

: 1374342-10-5
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-(2,2,2-trifluoroethyl)piperidine

: 1374342-54-7
2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 110 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / 1,4-dioxane / 3 h / 120 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 4 h / 90 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; sodium carbonate; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 769944-79-8
4-(4-bromophenyl)piperidine hydrogen chloride salt

: 1374342-54-7
2-fluoro-6-{4-methyl-4'-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]biphenyl-2-yl}pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.83 h / 45 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / 1,4-dioxane / 1.5 h / 95 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 110 °C

4: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate / 1,4-dioxane / 3 h / 120 °C / Inert atmosphere

5: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 4 h / 90 °C / Inert atmosphere; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; acetonitrile;