2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol

Base Information

• Chemical Name: 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol
• CAS No.: 54961-02-3
• Molecular Formula: C₁₄H₂₂O₄
• Molecular Weight: 254.326
• Mol file: 54961-02-3.mol

Synonyms:2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol

Chemical Property of 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol

There total 4 articles about 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methyl-4-(2,4,6-trimethoxyphenyl)-3-butyn-2-ol (157953-18-9) → 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol (54961-02-3)

Guidance literature:

With hydrogen; nickel; In methanol; at 20 ℃;

DOI:10.3987/COM-94-6744

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol (54961-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: I₂, CF₃CO₂Ag / CHCl₃ / Ambient temperature

2: 67 percent / PPh₃, Et₃N, PdCl₂, CuI / dimethylformamide / 21 h / 80 °C

3: H₂ / Raney Ni / methanol / 20 °C

With copper(l) iodide; hydrogen; iodine; silver trifluoroacetate; triethylamine; triphenylphosphine; palladium dichloride; nickel; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.3987/COM-94-6744

Reference yield:

2-iodo-1,3,5-trimethoxybenzene (2510-49-8) → 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol (54961-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / PPh₃, Et₃N, PdCl₂, CuI / dimethylformamide / 21 h / 80 °C

2: H₂ / Raney Ni / methanol / 20 °C

With copper(l) iodide; hydrogen; triethylamine; triphenylphosphine; palladium dichloride; nickel; In methanol; N,N-dimethyl-formamide;

DOI:10.3987/COM-94-6744

upstream raw materials:

2-Methyl-4-(2,4,6-trimethoxyphenyl)-3-butyn-2-ol

1,2,3-trimethoxybenzene

2-iodo-1,3,5-trimethoxybenzene

Downstream raw materials:

4-(2,4,6-trimethoxyphenyl)-2-methylbut-2-ene