2510-49-8

Usage

Type of compound

Organic compound

Structure

Benzene derivative with three methoxy groups (CH3O-) and one iodine atom attached to the benzene ring

Usage

Reagent in organic chemistry

Applications

Synthesis of various compounds and pharmaceuticals

Role

Precursor in the production of diverse chemical products

Potential applications

Medicine, agriculture, and material science

Significance

Plays a significant role in the field of organic chemistry

Reactivity

Unique chemical properties and reactivity contribute to its wide range of potential uses in various industries

InChI:InChI=1/C9H11IO3/c1-11-6-4-7(12-2)9(10)8(5-6)13-3/h4-5H,1-3H3

Upstream product

• 621-23-8 1,2,3-trimethoxybenzene 
• 116762-92-6 <<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>-(2,4,6-trimethoxyphenyl)iodonium trifluoroacetate 
• 105189-44-4 3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester 
• 609-08-5 Diethyl methylmalonate 
• 67-56-1 methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 570-02-5 2,4,6-trimethoxybenzoic acid 
• 75-05-8 acetonitrile 
• 100954-03-8 phenyl 3-phenylprop-2-ynoate 
• 117934-81-3 2,4-diiodo-1,3,5-trimethoxybenzene 
• 865-48-5 sodium t-butanolate 
• 147622-60-4 2,6-diiodo-3,5-dimethyoxyphenol 

Downstream Products

• 93236-66-9 2,2',2'',4,4',4'',6,6',6''-nonamethoxyterphenyl 
• 157953-18-9 2-Methyl-4-(2,4,6-trimethoxyphenyl)-3-butyn-2-ol 
• 866093-33-6 1,3,5-trimethoxy-2-(4-methoxyphenylethynyl)benzene 
• 866093-35-8 2,4,6-trimethoxy-2-(4-methoxyphenyl)benzofuran-3-one 
• 866093-34-7 1-(4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)-ethane-1,2-dione 
• 111222-93-6 2-hydroxy-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 136612-71-0 (2,4,6-Trimethoxyphenyl)acetylene 
• 54961-01-2 4-(2,4,6-trimethoxyphenyl)-2-methylbut-2-ene 
• 54961-02-3 2-(3-Hydroxy-3-methylbutyl)-1,3,5-trimethoxybenzol 

Relevant academic research and scientific papers

Visible-Light-Enabled Oxidative Alkylation of Unactivated Alkenes with Dimethyl Sulfoxide through Concomitant 1,2-Aryl Migration

Metal-free oxidative radical 1,2-alkylarylation of unactivated alkenes with the α-C(sp3)-H bond of dimethyl sulfoxide has been developed. This study realizes a new, conceptually novel technology for convenient construction of a variety of α-ary

Structure determination and total synthesis of a novel antibacterial substance, AB0022A, produced by a cellular slime mold

A novel antibacterial substance, AB0022A, was isolated from the cellular slime mold Dictyostelium purpureum K1001. It inhibited the growth of Gram-positive bacteria, and its MICs ranged from 0.39 to 50 μg/ml. Because AB0022A was a highly substituted aroma

Designing inhibitors against fructose 1,6-bisphosphatase: Exploring natural products for novel inhibitor scaffolds

Natural products often contain unusual scaffold structures that may be elaborated by combinatorial methods to develop new drug-like molecules. Visual inspection of more than 128 natural products with some type of anti-diabetic activity suggested that a su

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

Visible-light-promoted oxidative halogenation of (hetero)arenes

Organic halides are critical building blocks that participate in various cross-coupling reactions. Furthermore, they widely exist as natural products and artificial molecules in drugs with important physiological activities. Although halogenation has been well studied, to the best of our knowledge, studies focussing on sensitive systems (e.g.aryl amines) have not been reported. Herein, we describe a compatible oxidative halogenation of (hetero)arenes with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure). Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application.

Hypervalent-Iodine-Mediated Carbon–Carbon Bond Cleavage and Dearomatization of 9H-Fluoren-9-ols

A transition-metal-free synthesis of spiro compounds from 9H-fluoren-9-ols mediated by hypervalent iodine is reported. In this reaction, an unprecedented β-carbon elimination of tertiary alkoxyliodine(III) to form new diaryliodonium salts is proposed. The

Oxidative alkylation of alkenes with carbonyl compounds through concomitant 1,2-aryl migration by photoredox catalysis

Visible-light-enabled oxidative radical 1,2-alkylarylation of α-aryl allylic alcohols with carbonyl compounds has been established under mild conditions. An efficient and convenient protocol for the construction of a variety of 1,5-dicarbonyl compounds wa

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

H-bonding vs Protonation of Alkynes in Regioselective Hydroamination Reactions: A Glimpse into the Reactivity of Arylogous Ynolethers and Ynamines

In this paper is described the competition and transition between hydrogen bonding and protonation of alkynes connected, on one side, to various aromatic rings and to chiral amino ester appendages on the other side. While the first mode of activation indu