C₂₈H₂₆F₃N₃O₂

Base Information

• Chemical Name: C₂₈H₂₆F₃N₃O₂
• CAS No.: 1217503-79-1
• Molecular Formula: C₂₈H₂₆F₃N₃O₂
• Molecular Weight: 493.529
• Mol file: 1217503-79-1.mol

Synonyms:C₂₈H₂₆F₃N₃O₂

Chemical Property of C₂₈H₂₆F₃N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₆F₃N₃O₂

There total 4 articles about C₂₈H₂₆F₃N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine (92367-11-8) + N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) → C28H26F3N3O2 (1217503-79-1)

Guidance literature:

N-(diphenylmethylene)glycine tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine; In tetrahydrofuran; at 20 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c9cc09891g

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → C28H26F3N3O2 (1217503-79-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 0.08 h / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / 3 h / 70 °C / Inert atmosphere

3.1: pyridine / 3 h / Reflux; Inert atmosphere

4.1: ammonia / diethyl ether / 12 h / -78 - 20 °C / Sealed tube; Inert atmosphere

5.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C / Inert atmosphere

6.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 70 °C / Inert atmosphere

7.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

With pyridine; dmap; N-Bromosuccinimide; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; ammonia; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1039/c9cc09891g

Reference yield:

2,2,2-trifluoro-1-(p-tolyl)ethanone (394-59-2) → C28H26F3N3O2 (1217503-79-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine; hydroxylamine hydrochloride / 3 h / 70 °C / Inert atmosphere

2.1: pyridine / 3 h / Reflux; Inert atmosphere

3.1: ammonia / diethyl ether / 12 h / -78 - 20 °C / Sealed tube; Inert atmosphere

4.1: dipyridinium dichromate / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 70 °C / Inert atmosphere

6.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; ammonia; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;

DOI:10.1039/c9cc09891g

upstream raw materials:

3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine

N-(diphenylmethylene)glycine tert-butyl ester

2,2,2-trifluoro-1-(p-tolyl)ethanone

2,2,2-trifluoro-1-(4-methylphenyl)-1-ethanone oxime

Downstream raw materials:

C₁₁H₁₀F₃N₃O₂