4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

Base Information

Chemical Name:4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide
CAS No.:1229584-11-5
Molecular Formula:C₂₁H₁₆BrN₃O₃S
Molecular Weight:470.346
Hs Code.:

Synonyms:4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

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Chemical Property of 4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

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Technology Process of 4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

There total 4 articles about 4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 875639-15-9
5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 123088-59-5
4-carbamoylphenylboronic acid

: 1229584-11-5
4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 60 ℃; for 3h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1229584-11-5
4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 3 h / 60 °C

With sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetonitrile; mineral oil;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1229584-11-5
4-[5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / acetone / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 3 h / 60 °C

With N-iodo-succinimide; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetone; acetonitrile; mineral oil;