{4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate

Base Information

• Chemical Name: {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate
• CAS No.: 1433824-14-6
• Molecular Formula: C₃₈H₃₉FN₈O₄S
• Molecular Weight: 722.843

Synonyms:{4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate

Chemical Property of {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate

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Technology Process of {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate

There total 23 articles about {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.0^2,7]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-5-yl}phenyl}methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9-{[2-(trimethylsilyl)ethoxy]methyl}purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.02,7]trideca-1(9),2(7)-dien-5-yl}phenyl}methyl acetate (1433824-11-3) → {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.02,7]trideca-1(9),2(7)-dien-5-yl}phenyl}methyl acetate (1433824-14-6)

Guidance literature:

With trifluoroacetic acid; at 30 ℃; for 2h;

Reference yield:

2-Amino-6-chloropurin (10310-21-1) → {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.02,7]trideca-1(9),2(7)-dien-5-yl}phenyl}methyl acetate (1433824-14-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: methyl iodide; copper(l) iodide; isopentyl nitrite / tetrahydrofuran / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 4 h / 80 °C

4.1: sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; acetonitrile / 2 h / 100 °C

5.1: trifluoroacetic acid / 2 h / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; copper(l) iodide; sodium acetate; sodium hydride; triethylamine; trifluoroacetic acid; methyl iodide; isopentyl nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

1-(4-Nitrophenyl)piperazine (6269-89-2) → {4-fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9H-purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.02,7]trideca-1(9),2(7)-dien-5-yl}phenyl}methyl acetate (1433824-14-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium cyanoborohydride; zinc(II) chloride / methanol / 5 h / 50 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C

3: triethylamine / isopropyl alcohol / 4 h / 80 °C

4: sodium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; acetonitrile / 2 h / 100 °C

5: trifluoroacetic acid / 2 h / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; palladium 10% on activated carbon; hydrogen; sodium acetate; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; zinc(II) chloride; In methanol; ethanol; water; isopropyl alcohol; acetonitrile;

upstream raw materials:

2-bromo-4-fluoro-6-(1-oxo-3,4,5,6,7,8-hexahydrobenzothieno[2,3-c]pyridin-2(1H)-yl)benzyl acetate

2-Amino-6-chloropurin

6-chloro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-2-amine

6-chloro-2-iodo-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

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