(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one
CAS No.:922174-45-6
Molecular Formula:C₂₅H₃₇NO₅
Molecular Weight:431.572
Hs Code.:

Synonyms:(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

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Chemical Property of (4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

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Technology Process of (4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

There total 4 articles about (4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 922174-42-3
(4S,6'S)-3-[6'-methyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

: 74-88-4
methyl iodide

: 922174-45-6
(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

Guidance literature:: (4S,6'S)-3-[6'-methyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 ℃; Further stages.;
DOI:10.1271/bbb.69.2401

Reference yield:

: C₆H₅CH₂C₃H₃NO₂COCHCH(CH₂)2CHCH₃CH₂CH₂OC₅H₉O

: 922174-45-6
(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 8.60 g / H₂ / PtO₂ / ethyl acetate / 2 h

2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 80 percent / tetrahydrofuran / -78 °C

With hydrogen; sodium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate;
DOI:10.1271/bbb.69.2401

Reference yield:

: 137765-95-8
(S)-4-Methyl-6-(tetrahydro-pyran-2-yloxy)-hexanal

: 922174-45-6
(4S,2'S,6'S)-3-[2',6'-dimethyl-8'-(tetrahydro-2H-pyran-2-yloxy)octanoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzene / 96 h / 60 °C

2.1: 8.60 g / H₂ / PtO₂ / ethyl acetate / 2 h

3.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: 80 percent / tetrahydrofuran / -78 °C

With hydrogen; sodium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; benzene; 1.1: Wittig reaction;
DOI:10.1271/bbb.69.2401