7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine

Base Information

• Chemical Name: 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine
• CAS No.: 156601-68-2
• Molecular Formula: C₁₄H₁₃N₃OS
• Molecular Weight: 271.343
• Mol file: 156601-68-2.mol

Synonyms:7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine

Chemical Property of 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine

There total 7 articles about 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-Benzoyl-2-methyl-isothioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester (146386-17-6) → 2-Amino-3,5-dihydro-7-(phenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (132138-67-1) + 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine (156601-68-2)

Guidance literature:

With ammonia; In methanol; at 100 ℃; for 22h;

DOI:10.1021/jm00053a008

Reference yield:

methyl 3-amino-4-benzyl-1H-pyrrole-2-carboxylate (146385-89-9) → 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine (156601-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1 h / 0 - 20 °C

3: NH₃ / methanol / 22 h / 100 °C

With DBN; ammonia; In methanol; dichloromethane;

DOI:10.1021/jm00053a008

Reference yield:

((Z)-2-Cyano-3-phenyl-propenylamino)-acetic acid methyl ester → 7-benzyl-2-(methylthio)-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidine (156601-68-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

2: Na₂CO₃ / methanol / 24 h / Ambient temperature

3: 95 percent / CH₂Cl₂ / 1 h / Ambient temperature

4: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1 h / 0 - 20 °C

5: NH₃ / methanol / 22 h / 100 °C

With DBN; ammonia; sodium carbonate; In methanol; dichloromethane;

DOI:10.1021/jm00053a008

upstream raw materials:

3-(3-Benzoyl-2-methyl-isothioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester

methyl 3-amino-4-benzyl-1H-pyrrole-2-carboxylate

3-Amino-4-benzyl-pyrrole-1,2-dicarboxylic acid 1-ethyl ester 2-methyl ester

3-(3-Benzoyl-thioureido)-4-benzyl-1H-pyrrole-2-carboxylic acid methyl ester