2-bromo-3,5-difluoro-2'-methoxybiphenyl

Base Information

• Chemical Name: 2-bromo-3,5-difluoro-2'-methoxybiphenyl
• CAS No.: 1232345-13-9
• Molecular Formula: C₁₃H₉BrF₂O
• Molecular Weight: 299.115
• Mol file: 1232345-13-9.mol

Synonyms:2-bromo-3,5-difluoro-2'-methoxybiphenyl

Chemical Property of 2-bromo-3,5-difluoro-2'-methoxybiphenyl

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-bromo-3,5-difluoro-2'-methoxybiphenyl

There total 1 articles about 2-bromo-3,5-difluoro-2'-methoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-Methoxyphenylboronic acid (5720-06-9) + 1,2-dibromo-3,5-difluorobenzene (139215-43-3) → 2-bromo-3,5-difluoro-2'-methoxybiphenyl (1232345-13-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; at 90 ℃; for 9h; regioselective reaction; Inert atmosphere;

DOI:10.1055/s-0029-1219552

upstream raw materials:

2-Methoxyphenylboronic acid

1,2-dibromo-3,5-difluorobenzene

Refernces

• 1、 Sharif, Muhammad,Reimann, Sebastian,Villinger, Alexander,Langer, Peter. "One-pot synthesis of difluorinated ortho -terphenyls by site-selective suzuki-miyaura reactions of 1,2-dibromo-3,5-difluorobenzene". experimental part. p. 913 - 916. Retrieved 2010/07/06.