3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

Base Information

Chemical Name:3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide
CAS No.:1380291-85-9
Molecular Formula:C₁₉H₂₉N₃O₃
Molecular Weight:347.458
Hs Code.:

Synonyms:3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

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Chemical Property of 3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

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Technology Process of 3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

There total 4 articles about 3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380291-65-5
2-{3-[methoxy(methyl)carbamoyl]cyclobutyl}acetic acid

: 68176-57-8
4-(tert-butyl)-1,2-diaminobenzene

: 1380291-85-9
3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

Guidance literature:: With N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 1380291-85-9
3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran / 4 h / 3? activated molecular sieves; Reflux; Inert atmosphere

2: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.17 h

3: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.33 h / 0 °C

With 4-methyl-morpholine; N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hydroxide; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1380291-59-7
3-[2-(benzyloxy)-2-oxoethylidene]cyclobutane-1-carboxylic acid

: 1380291-85-9
3-{[(2-amino-4-tert-butylphenyl)carbamoyl]methyl}-N-methoxy-N-methylcyclobutane-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.17 h

2: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.33 h / 0 °C

With 4-methyl-morpholine; N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; palladium 10% on activated carbon; In ethanol; dichloromethane;