5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
CAS No.:187949-90-2
Molecular Formula:C10H8 F N3 O2
Molecular Weight:221.191
Hs Code.:2933199090
European Community (EC) Number:633-762-3
DSSTox Substance ID:DTXSID40409917
Wikidata:Q72437375
Mol file:187949-90-2.mol

Synonyms:5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid;187949-90-2;5-amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid;MFCD01569434;5-Amino-1-(4-fluoro-phenyl)-1H-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-fluorophenyl)-;ETHYLLOFLAZEPATE;SCHEMBL2792560;AMY3029;DTXSID40409917;AKOS002667764;AB09242;PS-6784;SY038496;BB 0219824;CS-0157494;FT-0707915;EN300-144425;A813194;5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid;5-azanyl-1-(4-fluorophenyl)pyrazole-4-carboxylic acid;5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylicacid

Suppliers and Price of 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylicAcid
50mg
$ 45.00

SynQuest Laboratories
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid 98%
1 g
$ 45.00

SynQuest Laboratories
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid 98%
5 g
$ 135.00

SynQuest Laboratories
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid 98%
25 g
$ 395.00

Matrix Scientific
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
5g
$ 1000.00

Matrix Scientific
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
1g
$ 300.00

Matrix Scientific
5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid
0.500g
$ 240.00

J&W Pharmlab
5-Amino-1-(4-fluoro-phenyl)-1H-pyrazole-4-carboxylicacid 96%
1g
$ 37.00

J&W Pharmlab
5-Amino-1-(4-fluoro-phenyl)-1H-pyrazole-4-carboxylicacid 96%
5g
$ 120.00

J&W Pharmlab
5-Amino-1-(4-fluoro-phenyl)-1H-pyrazole-4-carboxylicacid 96%
25g
$ 478.00

Total 24 raw suppliers

Chemical Property of 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

PSA：81.14000
LogP:1.87300
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:221.06005467
Heavy Atom Count:16
Complexity:269

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1N2C(=C(C=N2)C(=O)O)N)F

Technology Process of 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

There total 3 articles about 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 138907-68-3
ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 187949-90-2
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate; With lithium hydroxide; water; In methanol; for 17h; Heating / reflux;

With hydrogenchloride; In water; pH=7;

Reference yield:

: 2-cyano-3-ethoxypropanoic acid

: 371-14-2
4-fluorophenylhydrazine

: 187949-90-2
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: In ethanol; at 80 ℃; for 4h;
DOI:10.1016/j.bioorg.2020.103807

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 187949-90-2
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; water / Reflux

1.2: Reflux

2.1: water / ethanol / Reflux

With water; In ethanol; water;
DOI:10.1016/j.ejmech.2018.07.059