5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

Base Information

Chemical Name:5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester
CAS No.:249937-08-4
Molecular Formula:C₁₅H₁₁FN₄OS
Molecular Weight:314.343
Hs Code.:

Synonyms:5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

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Chemical Property of 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

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Technology Process of 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

There total 3 articles about 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 187949-90-2
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid

: 2127-03-9
2,2'-dipyridyldisulphide

: 249937-08-4
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

Guidance literature:: With triphenylphosphine; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 138907-68-3
ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 249937-08-4
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. LiOH / methanol / 16 h / Heating

2: PPh₃ / acetonitrile / 16 h / 20 °C

With lithium hydroxide; triphenylphosphine; In methanol; acetonitrile;
DOI:10.1021/jm050736c

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 249937-08-4
5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbothioic acid S-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / Heating

2: aq. LiOH / methanol / 16 h / Heating

3: PPh₃ / acetonitrile / 16 h / 20 °C

With lithium hydroxide; triphenylphosphine; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm050736c