2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

Base Information

Chemical Name:2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde
CAS No.:325685-62-9
Molecular Formula:C₂₄H₂₀N₄OS
Molecular Weight:412.515
Hs Code.:

Synonyms:2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

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Chemical Property of 2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

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Technology Process of 2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

There total 7 articles about 2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 325685-72-1
4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

: 325685-62-9
2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - -45 ℃; for 1h;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 127958-19-4
4-(methoxymethyl)-2-phenylpyrimidine

: 325685-62-9
2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 29.0 g / POCl₃ / 3 h / Heating

2.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

2.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

3.1: 9.47 g / aq. HCl / acetone / 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 20 h / 35 °C

4.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

5.1: 91 percent / BBr₃ / CH₂Cl₂ / 1.75 h / 0 - 20 °C

6.1: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1 h / -78 - -45 °C

With hydrogenchloride; oxalyl dichloride; boron tribromide; sodium hydride; dimethyl sulfoxide; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 2.1: Stille coupling / 6.1: Swern oxidation;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 325685-62-9
2-Phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOMe / methanol; ethanol / 21 h / Heating

2.1: 29.0 g / POCl₃ / 3 h / Heating

3.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

3.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

4.1: 9.47 g / aq. HCl / acetone / 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

5.2: tetrahydrofuran / 20 h / 35 °C

5.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

6.1: 91 percent / BBr₃ / CH₂Cl₂ / 1.75 h / 0 - 20 °C

7.1: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1 h / -78 - -45 °C

With hydrogenchloride; oxalyl dichloride; sodium methylate; boron tribromide; sodium hydride; dimethyl sulfoxide; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 3.1: Stille coupling / 7.1: Swern oxidation;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M