4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

Base Information

Chemical Name:4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine
CAS No.:325685-72-1
Molecular Formula:C₂₄H₂₂N₄OS
Molecular Weight:414.531
Hs Code.:

Synonyms:4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

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Chemical Property of 4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

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Technology Process of 4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

There total 6 articles about 4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 325685-61-8
6-(6-Methoxymethyl-2-phenylpyrimidin-4-yl)-4-propylsulfanyl[2,2']bipyridinyl

: 325685-72-1
4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1.75h;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 127958-19-4
4-(methoxymethyl)-2-phenylpyrimidine

: 325685-72-1
4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 29.0 g / POCl₃ / 3 h / Heating

2.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

2.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

3.1: 9.47 g / aq. HCl / acetone / 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 20 h / 35 °C

4.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

5.1: 91 percent / BBr₃ / CH₂Cl₂ / 1.75 h / 0 - 20 °C

With hydrogenchloride; boron tribromide; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 2.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 325685-72-1
4-Hydroxymethyl-2-phenyl-6-(4-propylsulfanyl[2,2']bipyridinyl-6-yl)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaOMe / methanol; ethanol / 21 h / Heating

2.1: 29.0 g / POCl₃ / 3 h / Heating

3.1: Pd(PPh₃)2Cl₂ / dimethylformamide / 24 h / 80 °C

3.2: aq. KF / diethyl ether; dimethylformamide / 0.67 h / 20 °C

4.1: 9.47 g / aq. HCl / acetone / 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

5.2: tetrahydrofuran / 20 h / 35 °C

5.3: 60 percent / ammonium acetate / acetic acid / 1 h / 80 °C

6.1: 91 percent / BBr₃ / CH₂Cl₂ / 1.75 h / 0 - 20 °C

With hydrogenchloride; sodium methylate; boron tribromide; sodium hydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 3.1: Stille coupling;
DOI:10.1002/1521-3765(20001117)6:22<4124::AID-CHEM4124>3.0.CO;2-M