2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine

Base Information

• Chemical Name: 2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine
• CAS No.: 808148-16-5
• Molecular Formula: C₃₈H₅₉N₃O₁₃SSi
• Molecular Weight: 826.05

Synonyms:2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine

Chemical Property of 2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine

There total 2 articles about 2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + 2'-(O-tert-butyldimethylsilyl)-3'-α-(N-benzyl methylenesulfonamido)-3'-deoxy-uridine (808148-15-4) → 2'-(O-tert-butyldimethylsilyl)-5'-N3-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine (808148-16-5)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2004.09.118

Reference yield:

2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine (459425-76-4) → 2'-(O-tert-butyldimethylsilyl)-5'-N3-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine (808148-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / sodium borohydride / ethanol / 2 h / 0 °C

2: 86 percent / DMAP / tetrahydrofuran / 20 °C

With dmap; sodium tetrahydroborate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tetlet.2004.09.118

upstream raw materials:

di-tert-butyl dicarbonate

2'-(O-tert-butyldimethylsilyl)-3'-α-(N-benzyl methylenesulfonamido)-3'-deoxy-uridine

2'-(O-tert-butyldimethylsilyl)-3'-(N-benzyl methylidenesulfonamido)-3'-deoxy-uridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 808148-16-5 2'-(O-tert-butyldimethylsilyl)-5'-N₃-bis(tert-butoxycarbonyl)-3'-α-(N-benzyl,N-tert-butoxycarbonyl methylenesulfonamido)-3'-deoxy-uridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send