1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

Base Information

Chemical Name:1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione
CAS No.:134169-12-3
Molecular Formula:C₃₀H₃₄O₉S
Molecular Weight:570.661
Hs Code.:

Synonyms:1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

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Chemical Property of 1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

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Technology Process of 1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

There total 7 articles about 1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 134169-11-2
1-<3-(methylthio)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

: 134169-12-3
1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00097a005

Reference yield:

: 50773-56-3
3-benzyloxy-4-hydroxybenzaldehyde

: 134169-12-3
1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.3 kg / bromine, sodium acetate / acetic acid / 45 h

2: 76 percent / copper / pyridine / 16 h / 95 °C

3: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

4: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

5: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

With bromine; sodium acetate; copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a005

Reference yield:

: 4815-96-7
3-bromo-4-hydroxy-5-benzyloxybenzaldehyde

: 134169-12-3
1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / copper / pyridine / 16 h / 95 °C

2: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

3: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

4: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

With copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a005