1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

Base Information

Chemical Name:1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester
CAS No.:1548630-92-7
Molecular Formula:C₂₅H₁₉F₂NO₇
Molecular Weight:483.425
Hs Code.:

Synonyms:1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

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Technology Process of 1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

There total 1 articles about 1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 103068-41-3
4-fluororesorcinol

: 337909-10-1
1-formyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

: 1548630-92-7
1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

Guidance literature:: With methanesulfonic acid; In diethyl ether; dichloromethane; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.1021/ja410031n

Reference yield: 60.0%

: 1548630-92-7
1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

: 825628-77-1
1-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

Guidance literature:: With methanesulfonic acid; at 110 ℃; for 2h;
DOI:10.1021/ja410031n

Reference yield:

: 1548630-92-7
1-(bis(2,4-dihydroxy-5-fluorophenyl)methyl)-4-oxo-4H-quinolizine-3-carboxylate ethyl ester

: 852057-94-4
1-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonic acid / 2 h / 110 °C

2: water; lithium hydroxide / ethanol / 1 h / 0 - 20 °C

With methanesulfonic acid; water; lithium hydroxide; In ethanol;
DOI:10.1021/ja410031n