2-Methoxy-5-phenyl-1,3-pentanediol

Base Information

Chemical Name:2-Methoxy-5-phenyl-1,3-pentanediol
CAS No.:88842-05-1
Molecular Formula:C₁₂H₁₈O₃
Molecular Weight:210.273
Hs Code.:

Synonyms:2-Methoxy-5-phenyl-1,3-pentanediol

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Chemical Property of 2-Methoxy-5-phenyl-1,3-pentanediol

Chemical Property:

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Technology Process of 2-Methoxy-5-phenyl-1,3-pentanediol

There total 12 articles about 2-Methoxy-5-phenyl-1,3-pentanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 88842-05-1
2-Methoxy-5-phenyl-1,3-pentanediol

Guidance literature:: Multi-step reaction with 6 steps

1: 1) lithium dicyclohexylamide / 1) -78 deg C, THF, 40 min, 2) a) -78 deg C, THF, 1h, b) room temperature, 1h

2: 190 mg / LiAlH₄ / diethyl ether

3: 287 mg / p-TsOH / tetrahydrofuran / 4 h / Ambient temperature

4: 322 mg / tetrabutylammonium hydroxide, t-BuOOH, OsO₄ / 2-methyl-propan-2-ol / 18 h / 0 °C

5: 95 mg / NaH / tetrahydrofuran / 2 h / Ambient temperature

6: 66 mg / 1N HCl / 14 h / Ambient temperature

With hydrogenchloride; tert.-butylhydroperoxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydroxide; sodium hydride; lithium dicyclohexylamide; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; tert-butyl alcohol;
DOI:10.1021/jo00181a020

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 88842-05-1
(2S,3R)-2-Methoxy-5-phenyl-pentane-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1: 1) lithium dicyclohexylamide / 1) -78 deg C, THF, 40 min, 2) a) -78 deg C, THF, 1h, b) room temperature, 1h

2: LiAlH₄ / diethyl ether

3: p-TsOH / tetrahydrofuran / Ambient temperature

4: tetrabutylammonium hydroxide, t-BuOOH, OsO₄ / 2-methyl-propan-2-ol / 0 °C

5: NaH / tetrahydrofuran / Ambient temperature

6: 1N HCl / Ambient temperature

With hydrogenchloride; tert.-butylhydroperoxide; osmium(VIII) oxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydroxide; sodium hydride; lithium dicyclohexylamide; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; tert-butyl alcohol;
DOI:10.1021/jo00181a020

Reference yield:

: 75553-23-0
(E)-5-phenyl-2-penten-1-ol

: 88842-05-1
2-Methoxy-5-phenyl-1,3-pentanediol

Guidance literature:: Multi-step reaction with 4 steps

1: 287 mg / p-TsOH / tetrahydrofuran / 4 h / Ambient temperature

2: 322 mg / tetrabutylammonium hydroxide, t-BuOOH, OsO₄ / 2-methyl-propan-2-ol / 18 h / 0 °C

3: 95 mg / NaH / tetrahydrofuran / 2 h / Ambient temperature

4: 66 mg / 1N HCl / 14 h / Ambient temperature

With hydrogenchloride; tert.-butylhydroperoxide; osmium(VIII) oxide; tetra(n-butyl)ammonium hydroxide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; tert-butyl alcohol;
DOI:10.1021/jo00181a020