5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester
CAS No.:1007875-07-1
Molecular Formula:C₁₂H₁₀FNO₂S
Molecular Weight:251.281
Hs Code.:
DSSTox Substance ID:DTXSID001202368

Synonyms:1007875-07-1;4-Thiazolecarboxylic acid, 5-(2-fluorophenyl)-2-methyl-, methyl ester;5-(2-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester;SCHEMBL269010;VFNLFNJVGWCWIM-UHFFFAOYSA-N;DTXSID001202368;AKOS005210954;Methyl 5-(2-fluorophenyl)-2-methyl-4-thiazolecarboxylate

Suppliers and Price of 5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:251.04162790
Heavy Atom Count:17
Complexity:290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=C(S1)C2=CC=CC=C2F)C(=O)OC

Technology Process of 5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

There total 3 articles about 5-(2-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007875-06-0
methyl 3-chloro-3-(2-fluorophenyl)-2-oxopropanoate

: 62-55-5
thioacetamide

: 1007875-07-1
methyl 5-(2-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate

Guidance literature:: In methanol; at 60 ℃;

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 1007875-07-1
methyl 5-(2-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / -60 - 20 °C / Inert atmosphere

2: methanol / 60 °C

With potassium tert-butylate; In tetrahydrofuran; methanol;