N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

Base Information

Chemical Name:N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester
CAS No.:1312769-97-3
Molecular Formula:C₂₁H₃₁ClN₂O₆
Molecular Weight:442.94
Hs Code.:

Synonyms:N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

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Chemical Property of N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

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Technology Process of N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

There total 2 articles about N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312769-96-2
(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1312769-97-3
N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

Guidance literature:: (2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid; glycine ethyl ester hydrochloride; With benzotriazol-1-ol; triethylamine; In acetonitrile; at 20 ℃; for 0.333333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 889857-63-0
(2S)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312769-97-3
N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 72 h / 20 °C / Cooling with ice

1.2: pH 2

2.1: triethylamine; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

2.2: 1 h / 20 °C

With sodium hydride; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; acetonitrile; mineral oil;

Reference yield:

: 1312769-97-3
N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

: 1312769-98-4
N-[(2S)-3-(methylamino)-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine

Guidance literature:: N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester; With methanesulfonic acid; In ethanol; at 40 ℃; for 14h;

With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 2h;

With hydrogenchloride; In water; at 80 ℃; for 0.5h;