(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

Base Information

Chemical Name:(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid
CAS No.:1312769-96-2
Molecular Formula:C₁₇H₂₄ClNO₅
Molecular Weight:357.834
Hs Code.:

Synonyms:(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

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Chemical Property of (2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

Chemical Property:

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Technology Process of (2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

There total 1 articles about (2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-63-0
(2S)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 74-88-4
methyl iodide

: 1312769-96-2
(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

Guidance literature:: (2S)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid; methyl iodide; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 72h; Cooling with ice;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 1312769-96-2
(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1312769-97-3
N-[(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoyl]glycine ethylester

Guidance literature:: (2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid; glycine ethyl ester hydrochloride; With benzotriazol-1-ol; triethylamine; In acetonitrile; at 20 ℃; for 0.333333h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 1312769-96-2
(2S)-3-[tert-butoxycarbonyl(methyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoic acid

: 1312769-95-1
(6S)-6-(5-chloro-2-methoxybenzyl)-1-methyl-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

1.2: 1 h / 20 °C

2.1: methanesulfonic acid / ethanol / 14 h / 40 °C

2.2: 2 h / 20 °C

2.3: 0.5 h / 80 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 60 °C

With methanesulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; acetonitrile;