ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Base Information

• Chemical Name: ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
• CAS No.: 187724-99-8
• Molecular Formula: C₉H₉N₃O₃
• Molecular Weight: 207.189
• Hs Code.: 2933990090
• Mol file: 187724-99-8.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 4,7-dihydro-4-oxo-, ethyl ester (9CI);4-Hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester;

Chemical Property of ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Chemical Property:

• Refractive Index: 1.674
• PSA: 88.10000
• Density: 1.468 g/cm³
• LogP: 0.84020
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

There total 2 articles about ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (187724-98-7) + orthoformic acid triethyl ester (122-51-0) → 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (187724-99-8)

Guidance literature:

5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester; orthoformic acid triethyl ester; at 140 ℃; for 1h;

With ammonia; In methanol;

Reference yield:

5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (187724-98-7) → 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (187724-99-8)

Guidance literature:

With formic acid; formamide; In N,N-dimethyl-formamide;

Reference yield: 100.0%

4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (187724-99-8) → ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (187725-00-4)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 4h; Heating / reflux;

upstream raw materials:

5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

orthoformic acid triethyl ester

Downstream raw materials:

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

Refernces

• 1、 -. "Substituted pyrrolopyrimidines and processes for their preparation". . . Retrieved 2008/06/13.