diethyl 5-amino -1H-pyrrole-2,4-dicarboxylate

Base Information

• Chemical Name: diethyl 5-amino -1H-pyrrole-2,4-dicarboxylate
• CAS No.: 187724-98-7
• Molecular Formula: C₁₀H₁₄N₂O₄
• Molecular Weight: 226.232
• Hs Code.: 2933990090
• Mol file: 187724-98-7.mol

Synonyms:1H-Pyrrole-2,4-dicarboxylicacid, 5-amino-, diethyl ester (9CI);5-Amino-1H-pyrrole-2,4-dicarboxylic aciddiethyl ester;

Chemical Property of diethyl 5-amino -1H-pyrrole-2,4-dicarboxylate

Chemical Property:

• Vapor Pressure: 5.81E-08mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 440.6 °C at 760 mmHg
• Flash Point: 220.3 °C
• PSA: 94.41000
• Density: 1.265 g/cm³
• LogP: 1.53150
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

Diethyl2-Amino-3,5-pyrroledicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 5-amino -1H-pyrrole-2,4-dicarboxylate

There total 3 articles about diethyl 5-amino -1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethyl Bromopyruvate (70-23-5) + ethyl β-amino-β-ethoxyacrylate hydrochloride (34570-16-6) → 5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (187724-98-7)

Guidance literature:

ethyl β-amino-β-ethoxyacrylate hydrochloride; With sodium ethanolate; In ethyl acetate; for 0.75h;

ethyl Bromopyruvate; In ethyl acetate; at 60 ℃; for 0.333333h;

Reference yield:

ethyl Bromopyruvate (70-23-5) + ethyl amidinoacetate (50551-10-5) → 5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (187724-98-7)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate;

Reference yield:

1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (7226-23-5) + ethyl Bromopyruvate (70-23-5) + ethyl amidinoacetate (50551-10-5) → 5-amino-1H-pyrrole-2,4-dicarboxylic acid diethyl ester (187724-98-7)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate;

upstream raw materials:

ethyl Bromopyruvate

ethyl amidinoacetate

1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

ethyl β-amino-β-ethoxyacrylate hydrochloride

Downstream raw materials:

4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Refernces

• 1、 -. "Substituted pyrrolopyrimidines and processes for their preparation". . . Retrieved 2008/06/13.