(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

Base Information

Chemical Name:(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane
CAS No.:198015-88-2
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

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Chemical Property of (1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

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Technology Process of (1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

There total 8 articles about (1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 198015-59-7
(S)-(+)-N-t-butoxycarbonyl-N-benzyl-2,2-dibromo-1-methylcyclopropylmethylamine

: N-benzyl-N-t-butoxycarbonyl-N-2-methylbuta-2,3-dienylamine

: Benzyl-((S)-2-bromo-1-methyl-cyclopropylmethyl)-carbamic acid tert-butyl ester

: 198015-88-2
(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

Guidance literature:: With methyllithium; In diethyl ether; for 0.5h; Yield given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(97)00988-5

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 198015-88-2
(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / tetrahydrofuran / 18 h

2: 40 percent / MeLi / diethyl ether / 0.5 h

With methyllithium; potassium carbonate; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4020(97)00988-5

Reference yield:

: 100-46-9
benzylamine

: 198015-88-2
(1R,4S,5S)-N-t-butoxycarbonyl-1-methyl-4-phenyl-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent Turnov_. / dimethylsulfoxide / 20 h

2: 95 percent / K₂CO₃ / tetrahydrofuran / 18 h

3: 40 percent / MeLi / diethyl ether / 0.5 h

With methyllithium; potassium carbonate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(97)00988-5