N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide
CAS No.:1446846-81-6
Molecular Formula:C₂₃H₁₄ClF₅N₂OS
Molecular Weight:496.888
Hs Code.:

Synonyms:N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

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Chemical Property of N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

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Technology Process of N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

There total 5 articles about N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60811-24-7
3,4-difluorobenzenethiol

: C₁₇H₁₀ClF₃N₂O

: 1446846-81-6
N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: 3,4-difluorobenzenethiol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

C₁₇H₁₀ClF₃N₂O; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 74426-51-0
4-(trifluoromethyl)phenylacetyl chloride

: 1446846-81-6
N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl acetamide / 0 - 20 °C

2.1: potassium carbonate; 1-methyl-pyrrolidin-2-one / 3 h / 90 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

3.2: 16 h / 20 °C

With 1-methyl-pyrrolidin-2-one; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 20925-27-3
4-amino-2-chlorobenzonitrile

: 1446846-81-6
N-(3-chloro-4-cyanophenyl)-3-[(3,4-difluorophenyl)sulfanyl]-2-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

1.2: 16 h / 20 °C

2.1: potassium carbonate; 1-methyl-pyrrolidin-2-one / 3 h / 90 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

3.2: 16 h / 20 °C

With 1-methyl-pyrrolidin-2-one; sodium hydride; potassium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;