Technology Process of KPU-252-B1
There total 8 articles about KPU-252-B1 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper diacetate; sodium L-ascorbate;
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
at 80 ℃;
for 0.25h;
Microwave irradiation;
DOI:10.1016/j.bmc.2010.10.055
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere
3: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C
4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
5: copper diacetate; sodium L-ascorbate / water; N,N-dimethyl-formamide; tert-butyl alcohol / 0.25 h / 80 °C / Microwave irradiation
With
lithium aluminium tetrahydride; copper diacetate; caesium carbonate; Dess-Martin periodane; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
3: Dess-Martin oxidation / 5: Huisgen's cycloaddition;
DOI:10.1016/j.bmc.2010.10.055
- Guidance literature:
-
Multi-step reaction with 4 steps
1: manganese(IV) oxide / acetone / 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
4: copper diacetate; sodium L-ascorbate / water; N,N-dimethyl-formamide; tert-butyl alcohol / 0.25 h / 80 °C / Microwave irradiation
With
manganese(IV) oxide; copper diacetate; caesium carbonate; sodium L-ascorbate;
In
water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
4: Huisgen's cycloaddition;
DOI:10.1016/j.bmc.2010.10.055
