N-{[3-(trifluoromethyl)phenyl]methylidene}aniline

Base Information

• Chemical Name: N-{[3-(trifluoromethyl)phenyl]methylidene}aniline
• CAS No.: 351-17-7
• Molecular Formula: C₁₄H₁₀F₃N
• Molecular Weight: 249.235

Synonyms:N-{[3-(trifluoromethyl)phenyl]methylidene}aniline

Chemical Property of N-{[3-(trifluoromethyl)phenyl]methylidene}aniline

Chemical Property:

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Technology Process of N-{[3-(trifluoromethyl)phenyl]methylidene}aniline

There total 1 articles about N-{[3-(trifluoromethyl)phenyl]methylidene}aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Trifluoromethylbenzaldehyde (454-89-7) + aniline (62-53-3) → N-{[3-(trifluoromethyl)phenyl]methylidene}aniline (351-17-7)

Guidance literature:

DOI:10.1021/ja01143a518

Reference yield: 77.0%

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) + N-{[3-(trifluoromethyl)phenyl]methylidene}aniline (351-17-7) → N-((4-(trifluoromethyl)-[1,1’-biphenyl]-2-yl)methyl)aniline

Guidance literature:

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane; N-{[3-(trifluoromethyl)phenyl]methylidene}aniline; With dodecacarbonyl-triangulo-triruthenium; 1-Phenylbut-1-en-3-one; In toluene; at 125 ℃; for 8h; Inert atmosphere; Green chemistry;

With triethylsilane; In toluene; at 80 ℃; for 3h; Inert atmosphere; Green chemistry;

DOI:10.1039/c9cc04072b

Reference yield: 71.0%

ethyleneglycol vinyl ether (764-48-7) + N-{[3-(trifluoromethyl)phenyl]methylidene}aniline (351-17-7) → (R)-N-(2-(1,3-dioxolan-2-yl)-1-(3-(trifluoromethyl)phenyl)ethyl)aniline

Guidance literature:

N-{[3-(trifluoromethyl)phenyl]methylidene}aniline; With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; magnesium sulfate; In toluene; at -10 ℃; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;

ethyleneglycol vinyl ether; In toluene; at -10 ℃; for 12h; enantioselective reaction; Schlenk technique; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01970

upstream raw materials:

3-Trifluoromethylbenzaldehyde

aniline

Downstream raw materials:

N-(3-(trifluoromethyl)benzyl)aniline

RhCl(η5-C5Me5)(N-(3-(triluoromethyl)benzylidene)aniline(1-)-κN,C6)

IrCl(η5-C5Me5)(N-(3-(triluoromethyl)benzylidene)aniline(1-)-κN,C6)

Refernces

Synthesis, structure analysis, biological activity and molecular docking studies of some hydrazones derived from 4-aminobenzohydrazide

10.1016/j.molstruc.2020.129354

This research presents the synthesis, structural analysis, biological activity, and molecular docking studies of eight hydrazones derived from 4-aminobenzohydrazide. The purpose of the study was to explore the potential of these compounds as antimicrobial agents, specifically against bacteria and fungi, and to understand their molecular interactions through docking studies. The researchers synthesized (E)-4-amino-N′-(substituted benzylidene) benzohydrazides (1-8) by condensing 4-aminobenzohydrazide with appropriate aldehydes in methanol. The synthesized compounds were characterized using various spectroscopic techniques, including FT-IR, 1H, and 13C NMR. The study concluded that compounds with electron-donating groups showed good antibacterial activity, while those with electron-withdrawing groups exhibited good antifungal activities. Molecular docking studies indicated that compounds 6 and 8 had excellent glide score values, suggesting their potential as inhibitors for Mycobacterium tuberculosis InhA protein, which plays a crucial role in the biosynthesis of mycolic acids in the mycobacterial cell wall.

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