{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

Base Information

Chemical Name:{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid
CAS No.:1241896-43-4
Molecular Formula:C₁₈H₁₅F₄N₇O₃S
Molecular Weight:485.422
Hs Code.:

Synonyms:{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

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Chemical Property of {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

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Technology Process of {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

There total 8 articles about {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1241898-52-1
ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

: 1241896-43-4
{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

Guidance literature:: ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 873075-57-1
ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-5-carboxylate

: 1241896-43-4
{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; lithium hydroxide / water; tetrahydrofuran / 6 h / 20 °C

1.2: pH 4

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

3.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.83 h / 20 °C

4.1: sodium azide; ammonium chloride / 1,4-dioxane / 16 h / 110 °C

5.1: triethylamine / tetrahydrofuran / 1 h / 80 °C

6.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

8.2: pH 2

With hydrogenchloride; sodium azide; oxalyl dichloride; water; ammonium chloride; triethylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 873075-58-2
2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxylic acid

: 1241896-43-4
{5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.83 h / 20 °C

3.1: sodium azide; ammonium chloride / 1,4-dioxane / 16 h / 110 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6.1: triethylamine / dichloromethane / 16 h / 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

7.2: pH 2

With hydrogenchloride; sodium azide; oxalyl dichloride; water; ammonium chloride; triethylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;