ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

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Chemical Name:ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate
CAS No.:1241898-52-1
Molecular Formula:C₂₀H₁₉F₄N₇O₃S
Molecular Weight:513.476
Hs Code.:

Synonyms:ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

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Chemical Property of ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

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Technology Process of ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

There total 7 articles about ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261951-82-0
3-fluoro-2-trifluoromethylbenzoyl chloride

: 1241898-10-1
ethyl {5-[2-(piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate hydrochloride

: 1241898-52-1
ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1241898-14-5
tert-butyl 4-{5-[2-(2-ethoxy-2-oxoethyl)-2H-tetrazol-5-yl]-1,3-thiazol-2-yl}piperazine-1-carboxylate

: 1241898-52-1
ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 873075-58-2
2-(4-[(tert-butoxy)carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxylic acid

: 1241898-52-1
ethyl {5-[2-(4-{[3-fluoro-2-(trifluoromethyl)phenyl]carbonyl}piperazin-1-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.83 h / 20 °C

3.1: sodium azide; ammonium chloride / 1,4-dioxane / 16 h / 110 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6.1: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; sodium azide; oxalyl dichloride; ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;