23-amine-silybin

Base Information

• Chemical Name: 23-amine-silybin
• CAS No.: 1326308-07-9
• Molecular Formula: C₂₅H₂₃NO₉
• Molecular Weight: 481.459
• Mol file: 1326308-07-9.mol

Synonyms:23-amine-silybin

Chemical Property of 23-amine-silybin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 23-amine-silybin

There total 6 articles about 23-amine-silybin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

23-azide-silybin (1326308-06-8) → 23-amine-silybin (1326308-07-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.06.049

Reference yield:

23-O-(4,4’-dimethoxytriphenylmethyl)silibinin (1326308-16-0) → 23-amine-silybin (1326308-07-9)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 20 °C

2: formic acid / dichloromethane / 0.5 h / 20 °C

3: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: hydrogenchloride; water / ethanol / 0.33 h / 50 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With pyridine; hydrogenchloride; formic acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2011.06.049

Reference yield:

3,5,7,20-O-tetra-acetyl-23-O-(4,4'-dimethoxytriphenylmethyl)-silybin (1326308-17-1) → 23-amine-silybin (1326308-07-9)

Guidance literature:

Multi-step reaction with 4 steps

1: formic acid / dichloromethane / 0.5 h / 20 °C

2: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: hydrogenchloride; water / ethanol / 0.33 h / 50 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With hydrogenchloride; formic acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2011.06.049

upstream raw materials:

23-O-(4,4’-dimethoxytriphenylmethyl)silibinin

3,5,7,20-O-tetra-acetyl-23-O-(4,4'-dimethoxytriphenylmethyl)-silybin

23-azide-silybin

silybin