1326308-16-0

Basic information

• Product Name: 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin
• Synonyms: 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin
• CAS NO: 1326308-16-0
• Molecular Weight: 784.816
• Mol File: 1326308-16-0.mol

Chemical Properties

• CAS DataBase Reference: 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin(CAS DataBase Reference)
• NIST Chemistry Reference: 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin(1326308-16-0)
• EPA Substance Registry System: 23-O-(4,4’-dimethoxytriphenylmethyl)silibinin(1326308-16-0)

Safety Data

• Hazardous Substances Data: 1326308-16-0(Hazardous Substances Data)

Upstream product

• 802918-57-6 silybin 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 76-83-5 trityl chloride 

Downstream Products

• 1326308-17-1 3,5,7,20-O-tetra-acetyl-23-O-(4,4'-dimethoxytriphenylmethyl)-silybin 
• 802918-29-2 3,5,7-triacetoxy-2-[3-(4-acetoxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one 
• 1326308-08-0 sodium silybin-23-O-(4-nitrophenyl)-phosphate 
• 1326308-07-9 23-amine-silybin 
• 1326308-06-8 23-azide-silybin 
• 1326308-21-7 C₃₁H₂₆NO₁₅P 
• 1326344-95-9 C₂₅H₂₂O₁₃S 
• 1326308-05-7 sodium silybin-23-O-sulphate 
• 1326308-09-1 3,5,7,20-O-tetra-acetyl-23-O-methansulfonyl-silybin 
• 1326308-20-6 (3,5,7,20-O-tetra-acetyl)-silybin-23-O-(4-nitrophenyl)-phosphate 
• 1326308-18-2 3,5,7,20-O-tetra-acetyl-23-O-sulphate silybin 

Relevant articles and documents

New silybin scaffold for chemical diversification: Synthesis of novel 23-phosphodiester silybin conjugates

Silybin is the major component (ca. 30%) of the silymarin complex extracted from the seeds of Silybum marianum, with multiple biological activities operating at various cell levels. As an ongoing effort toward the exploitation of natural products as scaffolds for chemical diversification at readily accessible positions, we present here an efficient synthetic procedure to obtain new 23-phosphodiester silybin conjugates with different labels. A key point in our approach is the new 3,5,7,20-tetra-O-acetylsilybin-23-phosphoramidite, useful for a variety of derivatizations following a reliable and well-known chemistry. The feasibility of the procedure has been demonstrated by preparing new 23-silybin conjugates, exploiting standard phosphoramidite chemistry. Georg Thieme Verlag Stuttgart · New York.

Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects

A series of neuroprotective hybrid compounds was synthesized by conjugation of the flavonolignan silibinin with natural phenolic acids, such as ferulic, cinnamic and syringic acid. Selective 7-O-esterfication without protection groups was achieved by appl

New C-23 modified of silybin and 2,3-dehydrosilybin: Synthesis and preliminary evaluation of antioxidant properties

Silybin is the major flavonolignan of silymarin and it displays a plethora of biological effects, generally ascribed to its antioxidant properties. Herein we shall describe an efficient synthetic strategy to obtain a variety of new and more water-soluble