(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Base Information

Chemical Name:(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one
CAS No.:1640128-67-1
Molecular Formula:C₂₁H₁₉Cl₂FO₂
Molecular Weight:393.285
Hs Code.:

Synonyms:(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

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Chemical Property of (3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Chemical Property:

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Technology Process of (3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

There total 8 articles about (3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 106-95-6
allyl bromide

: 1623432-61-0
(3S,5R,6R)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 1640128-67-1
(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at -40 - -10 ℃; for 3h; Inert atmosphere;

Reference yield:

: 6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 106-95-6
allyl bromide

: 1623432-61-0
(3S,5R,6R)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 1640128-67-1
(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 - -10 ℃; for 3h; Inert atmosphere;

Reference yield:

: C₂₁H₂₃Cl₂FO₃

: 1640128-67-1
(3R,5S,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 12 h / 20 °C

2: pyridinium p-toluenesulfonate / toluene / 1 h / Dean-Stark; Reflux

3: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 3 h / -40 - -10 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; pyridinium p-toluenesulfonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;