methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

Base Information

Chemical Name:methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate
CAS No.:1640128-56-8
Molecular Formula:C₁₉H₁₇Cl₂FO₃
Molecular Weight:383.247
Hs Code.:

Synonyms:methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

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Chemical Property of methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

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Technology Process of methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

There total 3 articles about methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1623432-55-2
1-(4-chloro-3-fluorophenyl)-2-(3-chlorophenyl)ethanone

: 80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7
methacrylic acid methyl ester

: 1640128-56-8
methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 13h; Inert atmosphere;
DOI:10.1021/jm501550p

Reference yield:

: 403-17-8
4-chloro-3-fluorobenzoic acid

: 1640128-56-8
methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 12.5 h / 0 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C

3.1: potassium tert-butylate / tetrahydrofuran / 13 h / 0 - 20 °C

With thionyl chloride; potassium tert-butylate; sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: methyl-4-chloro-3-fluorobenzoate

: 1640128-56-8
methyl 5-(4-chloro-3-fluorophenyl)-4-(3-chlorophenyl)-2-methyl-5-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: potassium tert-butylate / tetrahydrofuran / 13 h / 0 - 20 °C

With potassium tert-butylate; sodium hexamethyldisilazane; In tetrahydrofuran;