3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
• CAS No.: 1621317-74-5
• Molecular Formula: C₂₃H₂₃N₅O₅S
• Molecular Weight: 481.532

Synonyms:3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property of 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

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Technology Process of 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

There total 5 articles about 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + C12H8ClN3O4S (1621317-72-3) → 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-74-5)

Guidance literature:

at 160 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate (27697-60-5) → 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-74-5)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 26 h / 20 °C / Reflux

2: 0.67 h / 50 °C

3: thionyl chloride / toluene / 22 h / 20 °C / Reflux

4: 0.5 h / 160 °C

With thionyl chloride; In toluene;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

3-(2-hydroxyethyl)-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-70-1) → 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 22 h / 20 °C / Reflux

2: 0.5 h / 160 °C

With thionyl chloride; In toluene;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

1-(2-Methoxyphenyl)piperazine

C₁₂H₈ClN₃O₄S

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

ethyl 3-[(ethoxycarbonyl)amino]-5-nitro-1-benzothiophene-2-carboxylate

Downstream raw materials:

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno [3,2-d]pyrimidin-8-yl]benzamide

N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-2-phenylacetamide

N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-phenylbutanamide

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