(R)-1,3-butanediol 1-benzyl ether 3-benzoate

Base Information

• Chemical Name: (R)-1,3-butanediol 1-benzyl ether 3-benzoate
• CAS No.: 77564-45-5
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• Mol file: 77564-45-5.mol

Synonyms:(R)-1,3-butanediol 1-benzyl ether 3-benzoate

Chemical Property of (R)-1,3-butanediol 1-benzyl ether 3-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1,3-butanediol 1-benzyl ether 3-benzoate

There total 2 articles about (R)-1,3-butanediol 1-benzyl ether 3-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(-)-1,3-butanediol 1-benzyl ether (4799-69-3,77564-44-4,116838-24-5,77564-42-2) + benzoic acid (65-85-0,8013-63-6) → (R)-1,3-butanediol 1-benzyl ether 3-benzoate (77564-45-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4020(01)98857-X

Reference yield:

(S)-1,3-butanediol 1-benzyl ether 3-THP ether (77564-41-1,77610-96-9) → (R)-1,3-butanediol 1-benzyl ether 3-benzoate (77564-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 6 N HCl / methanol / 3 h / Ambient temperature

2: 5 g / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / Ambient temperature

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4020(01)98857-X

Reference yield: 72.7%

(R)-1,3-butanediol 1-benzyl ether 3-benzoate (77564-45-5) → (R)-(+)-1,3-butanediol 1-benzyl ether (77564-44-4)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1016/S0040-4020(01)98857-X

upstream raw materials:

(S)-(-)-1,3-butanediol 1-benzyl ether

benzoic acid

(S)-1,3-butanediol 1-benzyl ether 3-THP ether

Downstream raw materials:

(R)-(+)-1,3-butanediol 1-benzyl ether

(R)-1,3-butanediol 1-benzyl ether 3-THP ether