77564-44-4

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(+)-1,3-butanediol 1-benzyl ether is used as an intermediate for the synthesis of various pharmaceuticals. Its unique chiral properties make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-(+)-1,3-butanediol 1-benzyl ether serves as an intermediate in the synthesis of agrochemicals. Its role is crucial in creating effective and targeted solutions for agricultural applications.
Used in Organic Synthesis:
(R)-(+)-1,3-butanediol 1-benzyl ether is utilized as a solvent and a reagent in organic synthesis. Its versatility in this field allows for the creation of a wide range of compounds and materials.
Used in Materials Science:
(R)-(+)-1,3-butanediol 1-benzyl ether has potential applications in the development of new materials. Its unique properties contribute to the advancement of materials science, potentially leading to the creation of innovative and improved materials.
Used in Fine Chemicals Production:
(R)-(+)-1,3-butanediol 1-benzyl ether also acts as a building block in the production of various fine chemicals. Its integration in this process highlights its importance in the synthesis of specialized and high-quality chemical products.

Upstream product

• 77564-41-1 (S)-1,3-butanediol 1-benzyl ether 3-THP ether 
• 100-44-7 benzyl chloride 
• 4799-69-3 4-benzyloxy-2-butanol 
• 1414787-02-2 C₁₅H₂₀O₅ 
• 1414787-03-3 C₁₆H₂₂O₅ 
• 128385-64-8 acetic acid-(3-benzyloxy-1-methyl-propyl ester) 
• 106539-39-3 [(1R)-3-benzyloxy-1-methylpropyl] acetate 
• 70388-33-9 4-benzyloxybut-1-ene 
• 94426-72-9 2-(2-(benzyloxy)ethyl)oxirane 
• 77564-41-1 (R)-1,3-butanediol 1-benzyl ether 3-THP ether 
• 106539-38-2 3-(1-ethoxyethoxy)-butanol benzyl ether 
• 106539-38-2 (3S)-1-benzyloxy-3-(1-ethoxyethoxy)butane 
• 302924-75-0 (R)-((4-(benzyloxy)butan-2-yl)oxy)(tert-butyl)dimethylsilane 
• 71998-69-1 (S)-4-benzyloxy-1,2-butanediol 

Downstream Products

• 106539-40-6 3(R)-1-benzyloxy-3-phtalimidobutane 
• 106539-39-3 [(1R)-3-benzyloxy-1-methylpropyl] acetate 
• 77564-41-1 (R)-1,3-butanediol 1-benzyl ether 3-THP ether 
• 106539-41-7 3(S)-1-benzyloxy-3-phtalimidobutane 
• 121404-62-4 (R)-(+)-3-methylundecan-1-ol benzylether 
• 302924-75-0 (R)-((4-(benzyloxy)butan-2-yl)oxy)(tert-butyl)dimethylsilane 
• 121404-61-3 (R)-(-)-3-tosyloxybutan-1-ol benzylether 
• 107290-85-7 ((S)-3-Methyl-undecyloxymethyl)-benzene 
• 393109-23-4 (S)-((4-(benzyloxy)butan-2-yl)oxy)(tert-butyl)dimethylsilane 
• 77564-45-5 (R)-1,3-butanediol 1-benzyl ether 3-benzoate 
• 84184-35-0 Toluene-4-sulfonic acid 3-benzyloxy-1-methyl-propyl ester 
• 84184-35-0 Benzyl 3-tosyloxybutyl ether 

Relevant academic research and scientific papers

Enzyme-mediated enantioselective hydrolysis of soluble polymer-supported dendritic carbonates

The easy separation of optically active compounds from enzymatic kinetic resolution products by simple precipitation using poly(ethylene glycol) (PEG)-supported dendritic carbonates is disclosed. The water-soluble polymer-supported substrates were prepared by immobilization of (±)-1-phenylethanol onto a monomethoxy PEG (MPEG; av MW 5000) bearing a dendritic spacer through a carbonate linker. The enantioselective hydrolysis of the dendritic substrates of the 1st and 2nd generations using lipase from porcine pancreas (PPL; Type II, Sigma) smoothly proceeded, and a multimolecule of the corresponding (R)-alcohols was released from one molecule of the racemic substrates. The E values of the reactions at 0 °C in a mixed solvent (hexane/buffer = 9/1) were up to >200.

Stereoselective synthesis of resorcylic acid lactone Cochliomycin B

The total synthesis of 14-membered resorcylic acid lactone, Cochliomycin B has prescribed, in a convergent manner, from readily available starting materials, D-galactose, L-aspartic acid and ethyl acetoacetate. The key reactions involved in the synthesis are Julia-Kocienski olefination, E-selective Horner-Wadsworth-Emmons olefination and intramolecular lactonization.

Stereoselective total synthesis of C2-symmetric natural products pyrenophorol and its derivatives

A stereoselective total synthesis of 16-membered C2-symmetric macrodiolide Pyrenophorol, Tetrahydropyrenophorol and 4,4-diacetylpyrenophorol have been accomplished. The synthesis started from commercially available L-Aspartic acid and the key reactions involved are regioselective epoxide opening, CBS reduction, Pinnick oxidation and Mitsunobu dilactonization.

ACYLATED CATECHIN POLYPHENOLS AND METHODS OF THEIR USE FOR THE TREATMENT OF CANCER

Disclosed herein are acylated active agents and methods of their use, e.g., for modulating a cancer marker or for treating cancer.

ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS AND NONALCOHOLIC FATTY LIVER DISEASE

Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME

Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.

First Synthesis and Characterization of Stereoisomers of Choleretic Drug Dihydroxydibutylether

Dihydroxydibutylether (DHBE) is a choleretic drug used for the treatment of gallstone and hepatic disorders due to its choleretic activity and hepatoprotective action. The drug is a mixture of three regioisomers. The main regioisomer 3-(3-hydroxylbutoxy)-

Pheromone synthesis. Part 256: Synthesis of the four stereoisomers of 5,11-dimethylpentacosane, a new sex pheromone component of the male Galleria mellonella (L.), with high stereochemical purities as determined by the derivatization-HPLC analysis of the eight stereoisomers of 5,11-dimethyl-8-pentacosanol

Abstract All the four stereoisomers of 5,11-dimethylpentacosane (>96.8% purity) were synthesized via the stereoisomers of 5,11-dimethyl-8-pentacosanol, whose stereoisomeric compositions could be determined precisely by their low temperature HPLC analysis after derivatization. 5,11-Dimethyl-8-pentacosanol was prepared by a Grignard reaction between 3-methylheptylmagnesium bromide and 4-methyloctadecanal, both of which were prepared from the commercially available enantiomers of citronellal (97-98% ee). Alternatively, (R)-3-methyl-1-heptanol could be prepared from methyl (R)-3-hydroxybutanoate (100% ee). Pd/C-catalyzed hydrogenation of a 5-methyl-1-alkene caused partial racemaization at C-5.

First stereoselective total synthesis of Neocosmosin A: A facile approach

First stereoselective concise synthesis of Neocosmosin A, with in vitro binding affinity for human opioid and cannabinoid receptors, has been reported using readily available starting materials such as methylacetoacetate, cyclohexanone, and homoallyl alco

Enzyme-mediated enantioselective hydrolysis of dicarboxylic acid monoesters

The enzyme-mediated highly enantioselective hydrolysis of dicarboxylic acid monoesters was investigated. The racemic substrates, which were prepared by coupling of the corresponding alcohols with dicarboxylic anhydrides, were enantioselectively hydrolyzed by lipase from Candida antarctica (Novozym 435) in a buffer at 30 °C. The products were easily separated by a simple extraction procedure without laborious column chromatography to afford both enantiomers of the alcohols. We then determined that the dicarboxylic acid monoesters were suitable alternative substrates for the preparation of optically active alcohols.