ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

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Chemical Name:ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate
CAS No.:1421848-95-4
Molecular Formula:C₁₇H₁₆FN₃O₂S
Molecular Weight:345.397
Hs Code.:

Synonyms:ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

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Technology Process of ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

There total 1 articles about ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: ethyl 3-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 638-07-3
ethyl (2-chloroaceto)acetate

: 74-88-4
methyl iodide

: 1421848-95-4
ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

: 1421848-96-5
ethyl {2-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

Guidance literature:: ethyl 3-(4-fluorophenyl)-1H-pyrazole-4-carboxylate; methyl iodide; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

With water; sodium hydroxide; In ethanol; for 1h; Reflux;

ethyl (2-chloroaceto)acetate; Further stages;

Reference yield:

: 1421848-95-4
ethyl {2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetate

: 1421847-28-0
2-{2-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 2 h / Reflux

2: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 100 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;