N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Base Information

Chemical Name:N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:226559-35-9
Molecular Formula:C₂₇H₃₆N₂O₆S₂
Molecular Weight:548.725
Hs Code.:

Synonyms:N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 3 articles about N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 226559-35-9
N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, 2.) 10 percent aq. NaOH / 1.) THF, from 0 deg C to RT, 2.) THF, RT, 5 h

2: oxalyl chloride, DMF / tetrahydrofuran / 4 h

3: Et₃N, H₂O / tetrahydrofuran / 1.5 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; water; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1021/jm981117p

Reference yield:

: 226559-33-7
4-(3-benzyloxy-propoxy)-5-methoxy-2-nitro-benzoic acid

: 226559-35-9
N-(4-benzyloxypropoxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 4 h

2: Et₃N, H₂O / tetrahydrofuran / 1.5 h / Ambient temperature

With oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1021/jm981117p