2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid

Base Information

Chemical Name:2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid
CAS No.:1382998-76-6
Molecular Formula:C₂₀H₁₈F₃N₃O₃
Molecular Weight:405.376
Hs Code.:

Synonyms:2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid

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Chemical Property of 2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid

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Technology Process of 2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid

There total 6 articles about 2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382998-75-5
methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate

: 1382998-76-6
2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]-pyridin-2-yl}phenoxy)propanoic acid

Guidance literature:: methyl 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)-propanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With acetic acid; In tetrahydrofuran; methanol;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1382998-76-6
2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]-pyridin-2-yl}phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium acetate / water / 0.5 h / 95 °C

1.2: 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 70 °C / Cooling with ice

6.1: water; trifluoroacetic acid / 20 °C / Cooling with ice

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

With water; hydrogen; sodium acetate; sodium hydride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1382998-88-0
2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole-2-yl]pyridine

: 1382998-76-6
2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]-pyridin-2-yl}phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 65 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 70 °C / Cooling with ice

4: water; trifluoroacetic acid / 20 °C / Cooling with ice

5: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

With water; hydrogen; sodium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;