(S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole

Base Information

• Chemical Name: (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole
• CAS No.: 1350771-45-7
• Molecular Formula: C₂₇H₃₂Cl₂N₂O₂
• Molecular Weight: 487.469
• Mol file: 1350771-45-7.mol

Synonyms:(S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole

Chemical Property of (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole

There total 3 articles about (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-diol (1350771-56-0) → (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole (1350771-45-7)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c1gc15788d

Reference yield:

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane (1350771-53-7) → (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole (1350771-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: tetrachloromethane; triphenylphosphine / dichloromethane / 20 °C / Inert atmosphere

With tetrachloromethane; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c1gc15788d

Reference yield:

2,2’-methylenebis[(4R)-4-phenyl-4,5-dihydro-2-oxazole] (150639-34-2) → (S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole (1350771-45-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: tetrachloromethane; triphenylphosphine / dichloromethane / 20 °C / Inert atmosphere

With tetrachloromethane; n-butyllithium; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1039/c1gc15788d

upstream raw materials:

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-diol

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane

2,2’-methylenebis[(4R)-4-phenyl-4,5-dihydro-2-oxazole]