5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane

Base Information

• Chemical Name: 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane
• CAS No.: 1350771-53-7
• Molecular Formula: C₃₉H₆₂N₂O₄Si₂
• Molecular Weight: 679.103
• Mol file: 1350771-53-7.mol

Synonyms:5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane

Chemical Property of 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane

There total 1 articles about 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane (92511-12-1) + 2,2’-methylenebis[(4R)-4-phenyl-4,5-dihydro-2-oxazole] (150639-34-2) → 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane (1350771-53-7)

Guidance literature:

2,2'-methylenebis[(4R)-4-phenyl-4,5-dihydro-2-oxazole]; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1gc15788d

Reference yield: 69.0%

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane (1350771-53-7) → 5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-diol (1350771-56-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1gc15788d

Reference yield:

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-di(tert-butyl)dimethylsilane (1350771-53-7) → 1,1'-{5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9}bis-(1H-imidazole) (1350771-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 8 h / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 14 h / Inert atmosphere

With tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c1gc15788d

upstream raw materials:

1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane

2,2’-methylenebis[(4R)-4-phenyl-4,5-dihydro-2-oxazole]

Downstream raw materials:

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-diol

5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9-ditosylate

(S)-2-{1,9-dichloro-5-[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonan-5-yl}-4,5-dihydro-4-phenyloxazole

1,1'-{5,5-bis[(R)-4,5-dihydro-4-phenyloxazol-2-yl]nonane-1,9}bis-(1H-imidazole)