TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE
• CAS No.: 187237-37-2
• Molecular Formula: C11H17N3O2
• Molecular Weight: 223.275
• Hs Code.: 2933399990
• Mol file: 187237-37-2.mol

Synonyms:Carbamicacid, [5-(aminomethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester (9CI);(5-Aminomethylpyridin-2-yl)carbamicacid tert-butyl ester;

Chemical Property of TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 132-134℃
• Refractive Index: 1.568
• Boiling Point: 321.371 °C at 760 mmHg
• PKA: 12.38±0.70(Predicted)
• Flash Point: 148.16 °C
• PSA: 77.24000
• Density: 1.164 g/cm³
• LogP: 2.66060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

99%, ^*data from raw suppliers

2-(Boc-Amino)-5-(aminomethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE

There total 4 articles about TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

tert-butyl (5-cyanopyridin-2-yl)carbamate (902837-44-9) → 2-(tert-butoxycarbonyl-amino)-5-aminomethylpyridine (187237-37-2)

Guidance literature:

With ammonia; hydrogen; In methanol; at 20 ℃;

Reference yield: 38.0%

tert-butyl N-[5-({[(2,4-dichlorophenyl)methyl]amino}methyl)pyridin-2-yl]carbamate + 2,4-dichlorobenzaldeyhde (874-42-0) → 2-(tert-butoxycarbonyl-amino)-5-aminomethylpyridine (187237-37-2)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-(tert-butoxycarbonyl-amino)-5-aminomethylpyridine (187237-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / 20 °C

2: ammonia; hydrogen / methanol / 20 °C

With dmap; ammonia; hydrogen; triethylamine; In methanol;

upstream raw materials:

tert-butyl (5-cyanopyridin-2-yl)carbamate

di-tert-butyl dicarbonate

6-aminonicotinonitrile

2,4-dichlorobenzaldeyhde

Downstream raw materials:

C₁₈H₂₁N₃O₃

2-amino-5-aminomethyl-pyridine

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