ARA-S

Base Information Edit

Chemical Name:ARA-S
CAS No.:187224-29-9
Molecular Formula:C₂₃H₃₇NO₄
Molecular Weight:391.551
Hs Code.:
Mol file:187224-29-9.mol

Synonyms:L-Serine,N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraenyl]- (9CI)

Suppliers and Price of ARA-S

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Arachidonoyl-L-serine
100mg
$ 395.00

Cayman Chemical
N-Arachidonoyl-L-Serine ≥98%
10mg
$ 60.00

Cayman Chemical
N-Arachidonoyl-L-Serine ≥98%
5mg
$ 40.00

Cayman Chemical
N-Arachidonoyl-L-Serine ≥98%
1mg
$ 15.00

Cayman Chemical
N-Arachidonoyl-L-Serine ≥98%
25mg
$ 130.00

American Custom Chemicals Corporation
N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)-L-SERINE 95.00%
10MG
$ 610.00

American Custom Chemicals Corporation
N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)-L-SERINE 95.00%
5MG
$ 500.34

AK Scientific
N-Arachidonoyl-L-serine
10mg
$ 181.00

AK Scientific
N-Arachidonoyl-L-serine
1mg
$ 120.00

Total 4 raw suppliers

Chemical Property of ARA-S Edit

Chemical Property:

PSA：86.63000
LogP:5.08470

Purity/Quality:

98%Min ^*data from raw suppliers

N-Arachidonoyl-L-serine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature. N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model. However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC. The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.
Uses N-Arachidonoyl-L-serine is a novel neuroprotective endocannabinoid with weak affinity for CB1 and CB2 cannabinoid receptors. It is also a pro-angiogenic factor and a vessel dilator. Shows proneurogenic properties in vitro and invivo in mice model of traumatic brain injury. (1) Exhibits neuroprotection via ERK and Akt phosphorylation and induction of their downstream antiapoptotic pathways (2)

Technology Process of ARA-S

There total 7 articles about ARA-S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: ethyl 3-hydroxy-2-icosa-5,8,11,14-tetraenamidopropanoate

: 187224-29-9
3-hydroxy-2-icosa-5,8,11,14-tetraenamidopropanoic acid

Guidance literature:: ethyl 3-hydroxy-2-icosa-5,8,11,14-tetraenamidopropanoate; With lithium hydroxide monohydrate; water; In ethanol; at 20 ℃;

With potassium hydrogensulfate; pH=3;
DOI:10.1021/jm900227u